Royal Air Force Typhoon FGR4s have conducted a mission with French aircraft in a joint strike on an hidden munitions depot in Syria operated by the IS group, as stated by the UK's MoD.
The site, located using reconnaissance, was thought to be housing weapons and explosive materials, the announcement noted, and was situated in mountainous terrain just above the ancient city of Palmyra in central Syria.
"The RAF jets utilized precision-guided Paveway IV munitions to hit a series of entry passages down to the facility... early reports suggest the objective was successfully hit," the ministry announced.
There was no sign of any civilian casualties in the attack conducted Saturday night and every plane involved returned safely, the ministry further stated.
The British jets were supported by a Voyager aerial refuelling aircraft.
IS - alternatively referred to as ISIS - enforced extremist governance over parts of Iraq and Syria before its territorial defeat in 2019.
"This action shows the UK's leading role, and resolve to work closely with our allies, to eradicate any re-emergence of the terrorist group and their harmful and extremist ideologies in the area," the British Defence Secretary the Defence Secretary said.
UK warplanes have performed overwatch operations over Syrian airspace to "prevent any attempted resurgence" of IS following its military defeat at the battle of Baghuz in 2019, the MoD reported.
"I must thank all the members of the UK armed forces who took part in this mission for their expertise and their valour," he added. "They were among thousands of British personnel on duty over the holidays. This action, to eliminate terrorist threats who pose a risk to our security, shows how British military are always on standby, throughout the year, protecting the UK domestically and influential overseas."
Last December, the US military carried out what it termed a "large-scale strike" against IS targets in the country, subsequent to an ambush claimed the lives of two US servicemembers and a local interpreter in the Palmyra area.
The UN estimates IS still boasts between 5,000 and 7,000 militants in Iraq and Syria.